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ORIGINAL ARTICLE
Year : 2015  |  Volume : 21  |  Issue : 1  |  Page : 22-26

Effect of exposure to second-hand smoke on serum levels of N-terminal pro-brain natriuretic peptide


1 Department of Internal Medicine, Faculty of Medicine, Assiut University, Assiut, Egypt; College of Applied Medical Sciences, Al Dawadmi-Shaqra University, Saudi Arabia
2 Department of Medical Biochemistry, Faculty of Medicine, El-Fayoum University, Al Fayoum, Egypt

Correspondence Address:
Safaa A. A. Khaled
Department of Internal Medicine, Faculty of Medicine, Assiut University Hospital, Assiut University, Assiut 71111, Egypt

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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/1687-4625.155665

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Background and objectives Exposure to second-hand smoke is as hazardous as exposure to first-hand smoke, and can cause cardiovascular disease. N-terminal pro-B-type natriuretic peptide (NT-proBNP) is a valid negative biomarker of left ventricular (Lv) dysfunction. The current study investigated the effect of exposure to second-hand smoke on serum levels of NT-proBNP, aiming to use NT-proBNP as a screening tool of Lv dysfunction in passive smokers. Participants and methods A total of 60 passive smokers and 20 matched controls were enrolled in the study; their ages range from 20 to 35 years. History of cardiovascular or pulmonary disease was an exclusion criterion. Demographic, anthropometric, and passive smoking data were collected through a self-administered questionnaire and physical examination. The extent of passive smoking was assessed by calculating the pack per year history. Serum levels of NT-proBNP were measured using an electrochemiluminescence assay for each participant. Results Analysis of data showed that passive smokers were currently exposed to second-hand smoke, 91.7% were living with the smoker, and 8.3% smoker's colleagues. Serum levels of NT-proBNP were 251.2 ± 46.9 and 148.3 ± 29.7 pg/ml in passive smokers and controls, respectively. Also, there was a significant difference (P < 0.0001, 105.4 ± 11.64) in serum NT-proBNP between passive smokers and controls. Serum NT-proBNP was correlated with both the duration and the amount of exposure to second-hand smoke (r = 0.313 and 0.763, P = 0.015 and 0.0001, respectively). Interpretations and conclusion These results showed that exposure to second-hand smoke could increase serum levels of NT-proBNP. Accordingly, an elevated NT-proBNP could be a strong predictor of Lv dysfunction in passive smokers.


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