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Year : 2016  |  Volume : 22  |  Issue : 1  |  Page : 34-40

Wuchereria bancrofti microfilariae and quantitative circulating antigen detection in selected endemic areas in Egypt

1 Medical Parasitology Department, Kasr Al Ainy Faculty of Medicine, Cairo University, Cairo, Egypt
2 Malaria and Emerging Parasitic Diseases Laboratory (MAPELab), National Microbiology Center, Instituto De Salud Carlos III, Madrid, Spain

Correspondence Address:
Iman R Abdel-Shafi
MD,Medical Parasitology Department, Kasr Al Ainy Faculty of Medicine, Cairo University, El Manial, PO Box 11562, Cairo
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/1687-4625.182556

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Back ground and objective Wuchereria bancrofti is responsible for 90% of cases of lymphatic filariasis throughout the tropics and in some subtropical areas worldwide, including Egypt. To combat this disease, the WHO has launched a program aiming to eliminate lymphatic filariasis by the year 2020 in all the endemic countries using mass drug administration (MDA) to interrupt the disease's transmission. The aim of the present work was to study W. bancrofti infection in selected endemic areas in Egypt by performing parasitological examination and enzyme-linked immunosorbent assay (ELISA) antigen detection test, and to analyze the demographic, clinical, and MDA data of the study population in relation to W. bancrofti infection. Patients and methods A total of 300 blood samples were collected from residents in endemic areas in five governorates. Parasitological examination and Og4C3 ELISA test were performed to identify W. bancrofti infection. Results Microfilariae were identified in one individual while circulating filarial antigens (CFAs) were detected in 10 individuals. Statistical analysis of the collected data showed that CFAs were significantly higher in the male population than in the female population, whereas analysis regarding other demographic, clinical, and MDA data showed no statistical significance. Conclusion The study results showed that CFAs are still detected in endemic communities in Egypt, and that the prevalence is higher in the male population than in the female population. Although the Og4C3 ELISA test is a useful research tool for the study of W. bancrofti infections, its cost and format hinder its wide use in endemic areas.

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