• Users Online: 281
  • Home
  • Print this page
  • Email this page
Home About us Editorial board Ahead of print Current issue Search Archives Submit article Instructions Subscribe Contacts Login 
Year : 2017  |  Volume : 23  |  Issue : 3  |  Page : 135-140

The relation between serum osteoprotegerin level and coronary artery calcification in type 2 diabetes mellitus patients

1 Department of Internal Medicine Diabetes and Endocrinology, Faculty of Medicine, Cairo University, Cairo, Egypt
2 Department of Clinical and Chemical Pathology, National Research Center 2, Faculty of Medicine, Cairo University, Cairo, Egypt
3 Department of Radiodiagnosis, Faculty of Medicine, Cairo University, Cairo, Egypt

Correspondence Address:
Nashwa S Ghanem
Department of Internal Medicine Diabetes and Endocrinology, Faculty of Medicine, Cairo University, 30 E Thabit Street, Helwan, Cairo
Login to access the Email id

Source of Support: None, Conflict of Interest: None

DOI: 10.4103/kamj.kamj_24_17

Rights and Permissions

Background Osteoprotegerin (OPG) is considered as a possible link between bone and vascular disease. It is important to establish noninvasive methods for monitoring vascular changes such as biochemical markers of increased risk for cardiovascular disease events such as OPG, as cardiovascular morbidity is high in diabetics. Aim The aim of this study was to determine the relationship between coronary artery calcification (CAC) and OPG levels in type 2 diabetic patients in comparison with healthy controls. Patients and methods Our study included 45 type 2 diabetic patients without evidence of previous cardiovascular disease (by history and ECG) and 45 healthy age-matched and sex-matched individuals as control. All were submitted to full history, clinical examination, and lab investigations. Serum OPG concentration was measured by an enzyme-linked immunosorbent assay and CAC imaging was performed using noncontrast multidetector computed tomography. Results Significant coronary artery calcification score (CACS) (more than 10 Agatston units) was seen in 23 (51.11%) patients. OPG was significantly high in diabetic patients in comparison with controls, with a mean of 12.9±5.7 pmol/l in cases and 8.6±0.5 pmol/l in controls (P<0.001). The CACS was positively correlated with age and diabetes duration. The OPG was positively correlated with fasting blood sugar and diabetes duration. The CACS showed significant positive correlations with OPG. Conclusion Increased serum OPG in CAC that could be used for the early diagnosis of subclinical atherosclerosis allows for designing strategies to reduce the cardiovascular event rates in these patients. Further studies are important to establish the predictive value of increased OPG levels in diabetic vascular complications.

Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)

 Article Access Statistics
    PDF Downloaded11    
    Comments [Add]    

Recommend this journal