Year : 2017 | Volume
: 23 | Issue : 1 | Page : 12--17
Observational study of metabolic syndrome among renal transplant recipients in Kasr Al-Aini School of Medicine: a single-center study
Osama Mohammady Mohammed, Ahmed Abdalla Aly, Dawlat Abdel-Hamid Belal, Karim Magdy Soliman
Internal Medicine and Nephrology Department, Cairo University, Cairo, Egypt
The metabolic syndrome (MS) is a constellation of clinical abnormalities related to insulin resistance and inflammation. The syndrome is now recognized as a risk factor for diabetes and cardiovascular disease in the general population. Recent studies suggest that MS is common after kidney transplantation, also possibly being predictive of allograft loss and poor allograft function.
We studied the prevalence of MS in Egyptian kidney transplant recipients (from Kasr Al-Aini School of Medicine) and its correlation with C-reactive protein (CRP), serum uric acid (UA), alkaline phosphatase (ALP), different immunosuppressive intakes, and hepatitis C virus (HCV) in these patients.
Patients and methods
The present cross-sectional study was conducted in 2012 on 100 renal transplant recipients, 68 male (68%) and 32 female (32%), with stable kidney function (serum creatinine=1.5±1 mg/dl) in King Fahd Unit, Cairo University. All clinical and laboratory data were recorded, including serum creatinine, UA, cholesterol, triglyceride (TGL), low-density lipoprotein, high-density lipoprotein (HDL), ALP, CRP, and HCV Abs. The presence of MS was determined using NCEP-ATP III criteria, with BMI used in place of waist circumference.
Patients were divided into two groups – MS (group 1): 26 patients, 12 female (46.2%) and 14 male (53.8%), with a mean age of 34.46±9.69 years; and non-MS (group 2): 74 patients, 20 female (27%) and 54 male (73%), with a mean age of 27±8.33 years. There was a highly significant correlation (P≤0.001) between CRP and MS, BMI and diabetes mellitus, whereas the correlation between CRP and hypertension, ALP, HCV Abs, alanine aminotransferase (ALT), TGLs level, and HDL was insignificant.
Metabolic syndrome is prevalent in post-renal transplant patients. Serum CRP concentration correlates positively with metabolic syndrome in kidney transplantation patients. The age, weight, BMI, systolic and diastolic BP, serum triglycerides, ALT of MS group were significantly higher than in non-MS group. The duration of hypertension in the MS cases was significantly longer than in non-MS cases.
Ahmed Abdalla Aly
Lecturer of Internal Medicine and Nephrology at Cairo University, Postal code 11562, Cairo
|How to cite this article:|
Mohammed OM, Aly AA, Belal DA, Soliman KM. Observational study of metabolic syndrome among renal transplant recipients in Kasr Al-Aini School of Medicine: a single-center study.Kasr Al Ainy Med J 2017;23:12-17
|How to cite this URL:|
Mohammed OM, Aly AA, Belal DA, Soliman KM. Observational study of metabolic syndrome among renal transplant recipients in Kasr Al-Aini School of Medicine: a single-center study. Kasr Al Ainy Med J [serial online] 2017 [cited 2017 Sep 24 ];23:12-17
Available from: http://www.kamj.eg.net/article.asp?issn=1687-4625;year=2017;volume=23;issue=1;spage=12;epage=17;aulast=Mohammed;type=0