Year : 2018 | Volume
: 24 | Issue : 1 | Page : 7--13
Studying the correlation between transforming growth factor β1 and chitinase-3-like-1 in assessment of bronchial asthma severity
Farag Khalil1, Nagwa Abd El-Ghaffar Mohamed2, Essam Abo El-Yazed3
1 Department of Internal Medicine, Al-Azhar University, Egypt
2 Department of Microbiology and Immunology, Al-Azhar University, Egypt
3 Department of Clinical and Chemical Pathology, National Research Centre, Cairo, Egypt
Background Chronic inflammation and airway remodeling have important roles in asthma pathophysiology. Transforming growth factor β1 (TGF-β1) and YKL-40 play a very important role in the pathogenesis of asthma.
Aim The aim of this work was to find noninvasive biomarkers that may enable us to assess asthma severity as a surrogate for invasive bronchial mucosa biopsy. Therefore, we studied the correlation between TGF-β1 and YKL-40 and asthma severity.
Patients and method The work was done on 40 patients with asthma who were classified into two groups: 20 patients with mild asthma and 20 patients with severe but stable asthma. A third group of 20 normal participants was taken as control. Immunoglobulin E total, YKL-40, and TGF-β1 were determined in serum of all studied groups.
Results The results showed highly significant increased serum TGF-β1 and serum YKL-40 in patients with asthma compared with control group, and they were positively correlated with disease severity.
Conclusion We conclude that increased serum levels of TGF-β1 and YKL-40 may be a biological characteristic of asthma exacerbation.
Lecturer of Internal Medicine, Faculty of Medicine Al-Azhar University, Alhusein University Hospital, Internal Medicine Department 7th Floor
|How to cite this article:|
Khalil F, Abd El-Ghaffar Mohamed N, Abo El-Yazed E. Studying the correlation between transforming growth factor β1 and chitinase-3-like-1 in assessment of bronchial asthma severity.Kasr Al Ainy Med J 2018;24:7-13
|How to cite this URL:|
Khalil F, Abd El-Ghaffar Mohamed N, Abo El-Yazed E. Studying the correlation between transforming growth factor β1 and chitinase-3-like-1 in assessment of bronchial asthma severity. Kasr Al Ainy Med J [serial online] 2018 [cited 2018 Dec 15 ];24:7-13
Available from: http://www.kamj.eg.net/article.asp?issn=1687-4625;year=2018;volume=24;issue=1;spage=7;epage=13;aulast=Khalil;type=0